Prior studies from this laboratory found that vapor inhalation of THC using an e-cigarette based system decreases body temperature, with an observed nadir similar to the effects of 10-20 mg/kg THC, i.p. but with a duration of action that was much shorter . These studies also found anti-nociceptive effects of inhaled THC that were comparable in…
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Previous animal studies have reported that alcohol enhances the absorption and delivery of MA in the brain
The recommendations for DSM-5 substance use disorders represent the results of a lengthy and intensive process aimed at identifying problems in DSMIV and resolving these through changes in DSM-5. At the same time, the variable amount of evidence on some of the issues points the way toward studies aimed at further clarifications and improvements in…
There are several possible explanations for the link between major depressive disorders and chronic marijuana use
Depressive disorders have been associated with morphological brain abnormalities, although the majority of studies have been conducted in adults. Reduced hippocampal volumes have been found among depressed adults , although this may be associated with age of onset and one found no hippocampal differences . White matter abnormalities have also been associated with increased depressive symptoms and…
A significant portion of MAUCRSA is comprised of testing rules that aim to certify cannabis safety
Variables believed to be con-founders for this study encompassed population level and individual level variables that may affect the exposure and the outcome.These variables included state’s cannabis regulatory status, state’s COVID-19 infection prevalence, state’s percent urbanicity, age, sex, and education.State’s cannabis regulatory status is hypothesized as a con-founder as state’s legalization may be associated with state’s…
The names of workers have been altered in order to protect the anonymity and confidentiality of respondents
While there are many studies that focus on cannabis consumers – health outcomes and public safety issues related to the legalization and use of cannabis – little attention has been paid to workers in the industry.The small amount of occupational safety and health literature that does exist regarding the cannabis industry focuses on the biological, chemical,…
The self-reported use further indicates the need to study cannabis to understand its potential risks versus benefits
The lack of significant adverse effects in this study encourages further investigation into the use of cannabis-based interventions including CBD to treat chronic SCD pain in prospective trials with a larger cohort over a longer duration.Questionnaire-based approaches have provided insight into the prevalence of cannabis use in the SCD community, and these studies have given first-hand…
Some countries continue to criminalize all forms of medical and recreational uses of cannabis
The molecular alterations were consistent with the observed phenotypes, as stress exposure induced anxiety like behavior in offspring with pre-gestational WIN exposure, compared to controls without pre-gestational WIN exposure. The epigenetic changes in the offspring could have been due to direct epigenetic modifications on the sperm or testes, as well as related to disruptions in the…
Diabetes and cDSPN were controlled for in our statistical model and the effect of long-term cannabis use persisted
In Pearson-Dennett et al.’s study the average population age was between 24 and 25 years; however, in our study the average population was 45.4 years and any subtle walking gait changes observed in younger individuals may become more significant with aging due to age related changes in postural control, leading to balance disturbances. We also found that…
Studies of brain structural measures and cannabis use in youth and young adults also have produced mixed results
We combined data from different generations to serve as a comparison group for the Baby Boomer cohort. These different generations do not necessarily have the same prevalence of use or patterns of consumption. As a result, it would be inappropriate to use the results from this comparison group as predictive; for example, the observation of…
Limits on the over concentration of outlets in vulnerable neighborhoods and buffers around alcohol outlets were rare
Web-scraped data included the outlet address and offerings . We geocoded the addresses to 2019 block groups using the ArcGIS World Geocoding Service . are the most granular geographic level at which the Census Bureau reports demographic and socioeconomic characteristics, and are considered reasonable proxies for neighborhoods.32Covariates included in the adjustment set were factors hypothesized…