Notably, as commonly seen with other CM studies, patients ultimately earned approximately 50-60% of the maximum amount available in prizes in the $560 condition but only approximately 25-30% of the maximum amount available in prizes in the $250 condition = 14.52, p <.001. This and other studies examining the effect of the magnitude of rewards on outcomes suggest that…
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Alcohol misuse is one of the leading contributors to preventable mortality and morbidity worldwide
Prior studies from this laboratory found that vapor inhalation of THC using an e-cigarette based system decreases body temperature, with an observed nadir similar to the effects of 10-20 mg/kg THC, i.p. but with a duration of action that was much shorter . These studies also found anti-nociceptive effects of inhaled THC that were comparable in…
All behavioral responses were automatically recorded by Med Associates software
Most of the imputation strategies resulted in a significant improvement in estimates of substance use data when compared to estimates relying on complete case data, which was especially true in the case of a ‘rare’ outcome such as heroin use. However, MI performed the most favorably regardless of the prevalence of the outcome or the level…
There are several possible explanations for the link between major depressive disorders and chronic marijuana use
Depressive disorders have been associated with morphological brain abnormalities, although the majority of studies have been conducted in adults. Reduced hippocampal volumes have been found among depressed adults , although this may be associated with age of onset and one found no hippocampal differences . White matter abnormalities have also been associated with increased depressive symptoms and…
Initiating marijuana use in early adolescence is an important prognosticator for subsequent drug dependence
Data collection on state medical marijuana laws included gathering all state statutes and subsequent regulations, and validating information against publicly available data sources and through telephone calls with state officials. Throughout the study, we conducted regular updates to monitor changes in regulations and amendments to state laws . Analyses incorporated a dichotomous measure reflecting whether…
A significant portion of MAUCRSA is comprised of testing rules that aim to certify cannabis safety
Variables believed to be con-founders for this study encompassed population level and individual level variables that may affect the exposure and the outcome.These variables included state’s cannabis regulatory status, state’s COVID-19 infection prevalence, state’s percent urbanicity, age, sex, and education.State’s cannabis regulatory status is hypothesized as a con-founder as state’s legalization may be associated with state’s…
The surveillance of the adverse health effects of cannabis is also a key priority of the US FDA
Adult criminal justice systems are incorporating MI techniques through digital health interventions to reduce substance use and in staff trainings to promote overall harm reduction and associated consequences, but studies are with those already using substances.Our data suggests focusing on youth’s internal distress , and cannabis use expectancies, , for those in first-time legal contact…
The self-reported use further indicates the need to study cannabis to understand its potential risks versus benefits
The lack of significant adverse effects in this study encourages further investigation into the use of cannabis-based interventions including CBD to treat chronic SCD pain in prospective trials with a larger cohort over a longer duration.Questionnaire-based approaches have provided insight into the prevalence of cannabis use in the SCD community, and these studies have given first-hand…
Vasoactive SP and CGRP lead to neurogenic inflammation by stimulating vascular permeability in sickle mice
Alternatively, subtle mood dysregulation may be a risk-factor for riskier cannabis use consumption.Proposed theories accounting for these functional and behavioral differences in cannabis users may have multiple underlying etiologies.Chronic young adult cannabis users demonstrate abnormal CB1 receptor density in the ACC ; thus, frequent cannabis use may influence continued white matter myelination and gray matter pruning…
Additional research in this area is needed to better inform treatment interventions
Findings from this online survey of veterans recruited from a pro-marijuana legalization listserv showed that MC users had more PTSD symptoms and greater combat exposure than RC veterans as well as lower levels of alcohol use.Veteran research can greatly inform federal and state cannabis-related policies, which are in constant flux yet shifting toward more tolerant practices…