Although this was a small, non-controlled qualitative study without detailed cannabis use characterization, it was suggestive of cannabis’ positive effect on female sexual function and is consistent with the current report. In a similar interview-based study with 37 female cannabis, the authors found that frequent users reported increased sexual pleasure, orgasms, satisfaction, and intimacy compared…
The present survey results are limited by the small and nonrepresentative sample and the cross-sectional design
Moreover, several position papers and research reports highlight the fact that MC might not be appropriate for age-related conditions. For example, the Canadian Rheumatology Association concluded that there is insufficient beneficial evidence along with possible harm about the use of pharmaceutical cannabinoids in osteoarthritis, rheumatoid arthritis and back pain.The European Pain Federation asserted that cannabis-based…
The field should be committed to evaluating the efficacy of cannabis for these indications in large-scale RCTs
Many unregistered RCTs give undue attention to under powered, post hoc subgroup analyses. Those with for-profit sponsors may be analyzed and publicized in a way that is beneficial to the sponsor’s goals. Therefore, the presence of a large-scale RCT should be seen as a necessary but not sufficient condition to determine whether a drug is safe and…
Extracts from hemp roots were analysed for the presence of phytochemicals by GC-mass spectrometric analysis
The structures of the identified compounds, mass spectra, and calibration curves are provided as Supplementary material . The first method is based on the scavenging of the ABTS radical 2,2′ – azino-bis and the radical cation was produced by reacting 3.5 mM ABTS with 1.2 mM K2S2O8 in H2O. Before use, the mixture was stored…
The method presented seems to be suitable for providing information about a possible and recent consumption of cannabis
Therefore, the increased cytotoxicity observed by the encapsulated terpenes in the MTT assay may be explained by the potentially promoted calcium-mediated cell death resulted from the increased intracellular Ca2+ concentrations. In disagreement with our findings, a recent report that tested different terpenoids, including MC , found that these terpenoids had no activation effect on human…
Social support has been shown to be a protective factor against increased substance use
Overall, all prediction models with mental health measures resulted in only a small amount of explained variance regarding substance use. Despite a mental burden that was heightened compared to normative samples and a subgroup of individuals who increased their alcohol and nicotine use, the association between mental health and substance use increase was not strong.…
The KCl solution enabled EEG collection even through hair and without the need for abrading the participant’s scalp
Adolescents using combustible tobacco are 9 to 15 times more likely to use cannabis than non-smoking adolescents, while over half of U.S. adolescents between the ages of 12 and 17 years who smoke cigarettes report past-month use of cannabis . Co-use of cannabis and tobacco may interact, both acutely during co-administration and chronically over time,…
Studies have suggested that those with PTSD turn to cannabis when existing psychological or pharmacological interventions fail
Although the proportion of male and female participants was balanced in the control arm, the proportion of male participants was higher in the drug arms. This outcome highlights an important issue because, at least for nicotine use, sex-specific associations with D2-type receptor availability have been suggested. Nevertheless, the main results on nicotine were confirmed in…
The age of cannabis initiation is of critical importance in understanding the path from recreational to problematic use
However, catalytic and electrochemical processes have some limitations and are preferably considered for low volume and specified treatment processes. Furthermore, the conventional 2D electrochemical reactors have the limitations of low mass transfer. Therefore, the oxidation/reduction of compounds takes place at the surface of the electrode which increased the energy consumption . Additionally, chlorides are generally present…
The ability of cannabis to impact perioperative management extends beyond its psychoactive effects
There is also substantial evidence that regular cannabis users develop tolerance to some of the impairing effects of cannabis, particularly in the domain of cognitive function. This may explain why the majority of respondents in the present survey disagreed that their use of medical cannabis impairs their driving, and why frequency of use was strongly…