Vasoactive SP and CGRP lead to neurogenic inflammation by stimulating vascular permeability in sickle mice

Alternatively, subtle mood dysregulation may be a risk-factor for riskier cannabis use consumption.Proposed theories accounting for these functional and behavioral differences in cannabis users may have multiple underlying etiologies.Chronic young adult cannabis users demonstrate abnormal CB1 receptor density in the ACC ; thus, frequent cannabis use may influence continued white matter myelination and gray matter pruning…

Additional research in this area is needed to better inform treatment interventions

Findings from this online survey of veterans recruited from a pro-marijuana legalization listserv showed that MC users had more PTSD symptoms and greater combat exposure than RC veterans as well as lower levels of alcohol use.Veteran research can greatly inform federal and state cannabis-related policies, which are in constant flux yet shifting toward more tolerant practices…

Some countries continue to criminalize all forms of medical and recreational uses of cannabis

The molecular alterations were consistent with the observed phenotypes, as stress exposure induced anxiety like behavior in offspring with pre-gestational WIN exposure, compared to controls without pre-gestational WIN exposure. The epigenetic changes in the offspring could have been due to direct epigenetic modifications on the sperm or testes, as well as related to disruptions in the…

Diabetes and cDSPN were controlled for in our statistical model and the effect of long-term cannabis use persisted

In Pearson-Dennett et al.’s study the average population age was between 24 and 25 years; however, in our study the average population was 45.4 years and any subtle walking gait changes observed in younger individuals may become more significant with aging due to age related changes in postural control, leading to balance disturbances. We also found that…

Studies of brain structural measures and cannabis use in youth and young adults also have produced mixed results

We combined data from different generations to serve as a comparison group for the Baby Boomer cohort. These different generations do not necessarily have the same prevalence of use or patterns of consumption. As a result, it would be inappropriate to use the results from this comparison group as predictive; for example, the observation of…

Limits on the over concentration of outlets in vulnerable neighborhoods and buffers around alcohol outlets were rare

Web-scraped data included the outlet address and offerings . We geocoded the addresses to 2019 block groups using the ArcGIS World Geocoding Service . are the most granular geographic level at which the Census Bureau reports demographic and socioeconomic characteristics, and are considered reasonable proxies for neighborhoods.32Covariates included in the adjustment set were factors hypothesized…

Findings suggest increased amygdala volume in female users compared to female non-users

Future research might better characterize the legislative goals of the cannabis industry using additional review of campaign expenditures, legislative testimony, and using key informant interviews. According to the 2011 Monitoring the Future Study, marijuana remains the most commonly used illicit drug in adolescence in the United States, one of few increasing in prevalence. In fact,…

Non-infectious pulmonary diagnoses were more common in both marijuana and tobacco smokers

Participants were followed until their first incident diagnosis, loss to follow-up, death, or end of study in 2014, whichever came first. For each outcome, models were fit separately for HIV+ and HIV− participants using two time-varying variables for marijuana and tobacco smoking: Model 1, current marijuana smoking and prior two-year average tobacco smoking , and Model 2,…

The tone of media coverage of cannabis-related issues also becomes more favorable

In other words, the federal government acknowledged the states’ lead in matters related to drug enforcement and allowed them to treat cannabis as a regulatory rather than a criminal matter . Several groups opposed the legalization of the recreational use of cannabis, the strongest of which were the pharmaceutical and alcohol industries, police unions, private…

The designation of cannabis as a Schedule I drug was supposed to be a temporary measure

The difference between lived experience and official anti-cannabis propaganda raised a general skepticism toward state authority . Considering the growing awareness about the harmful effects of alcohol and tobacco consumption, the draconian measures against cannabis looked increasingly arbitrary and unreasonable. Cannabis supporters believed that prohibitory policies violated their constitutional rights to privacy and freedom of…