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An intermediate, reduced set of items considered in the subsequent analyses are presented in Table 2. In prediction analyses with early-onset marijuana use as the outcome, the most predictive items were three externalizing characteristics: destroys things belonging to his/her family or others,steals outside the home,and lying or cheating.We used these items to construct a preliminary…

The number of episodes of marijuana use over 3 months was also recorded at 15 weeks and 20 weeks of gestation. Other drug use was also recorded, including cocaine, amphetamines, substance 1 a scale between 10 and 90 generated using an algorithm involving age, income and education. A higher score indicates higher socioeconomic status.It is a…

Increased RD has been related to demyelination in neurodegenerative diseases such as multiple sclerosis,suggestive of a neurotoxic effect with early age of first use of marijuana. These findings taken together, and in line with previous studies,suggest that an earlier age of onset is associated with decreased coherence of white matter. Moreover, these results suggest that…

We found a main effect of group on net IGT scores, such that MJ+ had overall lower net IGT scores than HC. These findings may highlight differences in decision-making performance between young adult MJ+ and HC. Results from this study underscore the importance of interventions targeted at reducing risky decision-making in young adult MJ users.…

In a follow-up study in 2014, the whole blood of donors who had consumed cannabis had diminished platelet aggregation. The conclusion was drawn that endocannabinoid receptor agonists reduce platelet activation as well as aggregation, and as such might have potential in antithrombotic therapies. This anticoagulatory effect could counteract the surgeon’s attempts to create hemostasis within…

Factors informing opinions of cannabis use may include generational cohort, religious affiliation, media exposure, prior or current prescription and illicit drug use, and political affiliation. However, even as attitudes toward cannabis have improved, there remains a significant stigma attached to cannabis that needs to be addressed. Even though medicinal cannabis was legalized in California over 20…

We have identified a significant number of binding motifs to BHLHE40, BACH1, SPl1, NFKB1 , JUND, CEBPE, SRF, PRDM14, ATF4 and USF2. Mapping of genes regulated by these factors have revealed sub-clusters characterized by co-regulation. Interestingly, the visualization of effects of cannabis alone and of cannabis in the context of HIV suggests that the genes most affected by…

Cannabinoid biosynthesis in plants occurs in specialized biosynthetic organs called glandular trichomes on female flowers and leaves. Several studies use metabolic profiling of trichomes to demonstrate variation in trichome size, density, and relative concentration of cannabinoids . However, the genetic mechanisms underlying the developmental changes in trichomes and consecutive cannabinoid content are still unknown. Apart from…

An explanation for the effect of schizotypy on cognition can be developed from the aberrant salience hypothesis of schizophrenia, which postulates that an imbalance of dopamine levels in the dopamine receptor-associated salience network is associated with inappropriate allocation of salience to all stimuli. This then leads to the emergence of psychotic symptoms, with efficiency of…

Other authors propose two centers of domestication, one in the Caucasus , where the ancestor of hemp fiber domesticated biotypes  evolved, and another in south-eastern China, the place where the precursor of narcotic domesticates  originated . The idea of at least two domestication centers situated in Europe and Asia is supported by archaeobotanical studies using…