Cannabinoid biosynthesis in plants occurs in specialized biosynthetic organs called glandular trichomes on female flowers and leaves. Several studies use metabolic profiling of trichomes to demonstrate variation in trichome size, density, and relative concentration of cannabinoids . However, the genetic mechanisms underlying the developmental changes in trichomes and consecutive cannabinoid content are still unknown. Apart from…
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Cannabis use can result in a temporary relaxation of dysphoria and anxiety
An explanation for the effect of schizotypy on cognition can be developed from the aberrant salience hypothesis of schizophrenia, which postulates that an imbalance of dopamine levels in the dopamine receptor-associated salience network is associated with inappropriate allocation of salience to all stimuli. This then leads to the emergence of psychotic symptoms, with efficiency of…
The Mediterranean biome and its climatic features are better suited than its Eurosuberian counterpart for the growth of Cannabis
Other authors propose two centers of domestication, one in the Caucasus , where the ancestor of hemp fiber domesticated biotypes evolved, and another in south-eastern China, the place where the precursor of narcotic domesticates originated . The idea of at least two domestication centers situated in Europe and Asia is supported by archaeobotanical studies using…
CBD is a common non-intoxicating cannabinoid constituent of cannabis
Among US adults , daily cannabis use was significantly more common among those with past-month serious psychological distress , compared to those without past-month SPD Systematic reviews have found associations between frequent cannabis use and hyperemesis syndrome , especially among young individuals reporting cannabis use, though co-occurring mental health problems appear common . In a meta-analytic…
New South Wales also has a separate offence of driving with the presence of morphine in the driver’s blood or urine
In addition to the labelling and warning system, most Australian jurisdictions also have offences relating to driving under the influence of alcohol or other drugs . These offences usually require a level of impairment in driving capacity caused by alcohol or other drug use, with this assessed based on evidence of a driver’s behaviour witnessed…
Secondhand smoke from cannabis may pose a similar risk to public health as tobacco SHS
The results of the mediation analysis did not support the hypothesis that changes in perceptions of the proportion of people who used cannabis between baseline and three-months were positively associated with reduction in the participant’s risky cannabis use at six-month follow-up . The analyses also did not demonstrate any evidence that these changes in perceptions…
Bootstrapping was used to calculate a bias-corrected confidence interval for the indirect effect
However, many cannabis users are interested in receiving self-help materials to help them evaluate their own cannabis use without formal treatment . It is possible then, that this emerging health issue could be partially addressed through the development, evaluation and dissemination of scalable interventions that can be self-administered by people who engage in risky cannabis…
A clear increase in clinic volume was observed as well as the effectiveness of the comprehensive screening process to admit eligible patients to the clinic
Recommendations for the use of safe and consistent products with certified laboratory testing and approval from the authorized regulatory agency is also essential. Following the appointment, a consultation report is sent to referring physicians including the detailed treatment plan, follow-up frequency and any specific recommendations such as monitoring of potential risk factors, adverse effects or…
Cannabinoids for rheumatic pain still constitute off label use
Rheumatic diseases are an important cause of chronic pain, usually difficult to treat with current analgesic treatments,and in the absence of a cure for the disease, the treatment of pain should be an important part of the integral management.Analgesic treatment consisting on NSAID, antidepressants and opioids are effective only in 10 to 25% of patients,and…
The endocannabinoid system is expressed throughout the ascending and the descending pathway
During the last decade, interest in cannabis in medicine has been increasing, and several countries, including United States and Canada, have produced their own legislation about marijuana and cannabis-based medicines.In 2017, 38 states and the District of Columbia allowed medical use of cannabis, and 8 states and the District of Columbia have legalized its recreational…