The Δ9 -THC-induced suppression of conditioned nausea could be reversed by a CB1 receptor antagonist/reverse agonist , implicating the CB1 receptor in this effect . Limebeer et al. demonstrated that, unlike OND, Δ9 -THC also interfered with the expression of conditioned gaping elicited by the LiCl paired contextual cues in rats. This finding was consistent with…
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Cumulative total was displayed after trial completion to allow performance monitoring
If con- firmed in further behavioral models, these findings would suggest that inhibition of intracellular FAAH activity might offer an innovative target for the treatment of anxiety , which is also a feature of marijuana withdrawal .2-AG was identified as a second endocannabinoid substance in 1995 . The multiple roles of this lipid compound in cell metabolism…
A study with a larger sample size is needed to confirm this intriguing association
Locally produced anandamide also may be involved in the regulation of gastric emptying and intestinal peristalsis, two processes that are inhibited by this endocannabinoid . Thus, intestinal anandamide appears to serve as an integrative signal that concomitantly regulates food intake and gastrointestinal motility. The predominant peripheral component of feeding suppression induced by SR141716A led us…
Terms were further excluded if no associated article links generated sufficient engagement
Ten terms were then selected based on having the highest total engagements for BuzzSumo interrogation: fertility in men, low sperm treatment, male fertility, male fertility testosterone, male infertility, semen analysis, sperm count, sperm motility, sperm quality, and sperm testosterone.Fig. 1 summarizes the workflow for selecting article links from final search term results. The most popular article…
This assumption is potentially problematic as economic policies are not randomly assigned
There appears to be little difference between genders in the mortality rate due to drug suicide. In addition, the table indicates that less-educated adults are more likely than college graduates to be nonwhite, uninsured and to live in a rural area. Figures 1 plots average cause-specific death rates for less-educated adults over the 1999-2015 period.…
Conditional analyses also suggested independent associations in the chromosome 2 region
Among these arrays, 2 to 127 samples were genotyped on at least two different arrays with pairwise concordance rates all >99.18%. A set of 47 000 variants genotyped on all arrays and meeting the following four criteria: common , independent , high quality , were used to assess duplicate samples included on multiple arrays and…
Region of significance analyses were computed using the jtools package in R statistical software
Recent alcohol use was assessed via the HNRP Substance Use History form. This form is a modified timeline follow-back measure that assesses alcohol use metrics including the quantity and frequency of alcohol use in the last 30 days . The variable capturing the total number of drinks consumed in the last 30 days was calculated…
We selected cases for this series from the toxicology consult service database for patients suspected of SC use
To approximate effects on such a short time frame, we also examined the association between change in psychiatric problems and contemporaneous change in substance use. We followed the same modeling strategy as in our primary models, but adjusted for one-year-lagged versions of all covariates . Table 6 presents the rate of contemporaneous changes in substance…
Our sensitivity analysis suggested that this result was not due to high utilizers leaving the KPNC healthcare system
Patients with deductible plans that do not include SUD as a covered benefit are responsible for bearing the cost of those services until their deductible is reached, and/or the accumulating cost of copays for multiple visits as part of the SUD care model. We did not include type of insurance as a covariate due to its…
Issues of ethnic classification continue to play an important role in health research
Researchers use this data to track the extent to which ethnic groups consume drugs and alcohol, exhibit specific alcohol and drug using practices and develop substance use related problems. In so doing, particular ethnic minority or immigrant groups are identified as high risk for developing drug and alcohol problems. In order to monitor the extent…