It has also been shown that cannabinoid antagonists can prevent drug reinstatement with cocaine, alcohol, and nicotine. Thus, it seems that the future of cannabinoid antagonists in substance abuse treatment is particularly promising, especially in the clinical setting, where polydrug abuse is exceedingly more common than isolated single-drug abuse.The available data suggest that CB1 antagonism…
All posts in November 2023
ERO power in a task that elicits a P3 response is also associated with a number of SNPs in the CHRM2 gene
Further exclusion criteria for ALC and CON are described elsewhere. In brief, ALC and CON participants were excluded for neurological disorders , psychiatric disorders , and medical and vascular risk factors , known to affect neurobiology or cognition as well as for MRI contraindications. In OD and ALC, hepatitis C, type-2 diabetes, hypertension, unipolar mood…
HVLT-R and BVMT-R recognition Z-scores were averaged to create a recognition composite
Epidemiological studies have shown that persons taking anti-inflammatory drugs for diseases such as rheumatoid arthritis had a reduced risk of developing AD . Moreover, small, randomized control trials examining anti-inflammatory drugs such as TNF-a inhibitors , though preliminary, have yielded encouraging results . If larger studies show that anti-inflammatory drugs can lower the risk of…
The TreeNet analysis revealed a set of predictors for SUD containing those derived by CART
ARPA accounts for the effect of hidden interactions better than alternative methods, and is independent of the type of data and of the type of data distribution. Furthermore, results supplied by tree-based analytics are easy to interpret visually and logically. Therefore, to generate the most comprehensive and parsimonious classificatory model to predict the susceptibility to disruptive behaviors,…
The effects of FAAH inhibition on drug reward have been the focus of several recent papers
This suggests that it may be preferable to assess the role of anandamide in drug reward processes by measuring changes in anandamide levels directly produced by administration of the drug rather than changes in anandamide levels produced after chronic drug exposure, when alterations may be opposite to those after acute administration and may reflect biochemical…
The cannabinoid antagonist rimonabant fully prevents heroin-induced reinstatement of heroin-seeking behavior
The results of a Phase II clinical trial with BAY-387271 are awaited with great excitement. Also highlighted during the conference were various derivatives of cannabidiol. Particularly interesting in this regard was the compound -7-hydroxy-4#- dimethylheptyl-cannabidiol a hydroxylated, dimethylheptylated cannabidiol, structurally related to HU-210. Like D9 -THC, 7-OH-DMH-CBD is a potent inhibitor of electrically evoked contractions in…
No additional compensation was offered for additional time in the study
It remains unknown whether neural abnormalities stimulated by early heavy alcohol use persist throughout the lifespan or revert to normative patterns after periods of short or long-term abstinence. fMRI studies provide a framework for understanding the regions of the brain associated with risky decision-making. The process of making a decision involves three distinct stages: 1)…
Data were collected by trained personnel who were not blinded to the objectives of study
A study by Jenkin et al.revealed a role of CB2 receptor activation in reducing the progression of obesity-related kidney dysfunction by decreasing proteinuria, creatinine clearance, and renal fibrotic markers. In contrast, ZDF rats treated with a CB1 inverse agonist showed improved renal structure and function.Surprisingly, these rats also displayed a marked increase in body weight…
Changes in tissue morphometry are attributable to synaptic proliferation and pruning as well as myelination
Decreases in AD may be attributable to developing axon collaterals, whereas increases may reflect growth in axon diameter, processes which are both likely to occur during adolescence. Technical and demographic differences such as imaging parameters, inter-scan intervals, age range, and gender ratios may account for divergent findings. Both grey matter volume decreases and FA increases…
The dot-probe task measures attentional biases toward or away from threatening stimuli
During standard prenatal care, pregnant women are screened for frequency of substance use in the year before pregnancy and during pregnancy via a self-administered questionnaire at the first prenatal visit . Our study sample included all pregnant women aged 11 years and older who completed the self-administered questions about use of alcohol and nicotine in…