Sahin et al. found that not only is the frequency of childhood trauma higher among high-risk participants compared to healthy controls, but also that childhood trauma was related to baseline severity of positive symptoms. Others have found that the intensity of perceptual abnormalities are higher among groups that have experienced physical abuse and other trauma compared to those without a history of trauma, and that CHR participants who report experiencing childhood trauma have poorer premorbid functioning compared to controls. Yung et al. recently found that childhood maltreatment, as assessed by the Childhood Trauma Questionnaire, was a significant predictor of poor functioning in CHR groups, as well as those who eventually transition. There are only two high-risk studies that we are aware of that have specifically investigated the relationship between trauma and conversion to psychosis. Both of these studies found that the majority of CHR participants experienced a traumatic event, and that sexual trauma was associated with increased risk of transitioning to psychosis. We have previously reported on childhood trauma among CHR individuals from the first half of the North American Prodromal Study . We found that CHR participants reported significantly more bullying and trauma compared to healthy controls, and that those who experienced past trauma and bullying were more likely to have increased levels of depression, anxiety,metal grow table with wheels as well as a poorer sense of self. Much less is available in the literature regarding the experience of perceived discrimination among those at risk for psychosis.
One recent population level sample found that perceived discrimination at moderate to high levels predicted self-reported psychotic experiences in a linear dose–response fashion. To the best of our knowledge, the only study investigating perceived discrimination among a CHR sample was also from the first half of the NAPLS-2 cohort. In this study CHR participants endorsed significantly more perceived discrimination compared to healthy controls, and this was associated with negative schemas about the self and others. The goal of this study was to determine whether our preliminary baseline findings for the first half of the NAPLS sample held in the final NAPLS-2 sample and additionally to determine whether trauma and perceived discrimination predict later transition to psychosis. The sample consisted of 764 CHR participants and 280 healthy controls . All participants were recruited as part of the NIMH funded North American Prodrome Longitudinal Study 2 and were drawn from the participating NAPLS 2 sites . The NAPLS-2 project was established to investigate predictors and mechanisms of conversion to psychosis. All CHR participants met the criteria of psychosis-risk syndromes using the structured interview for psychosis-risk symptoms. Participants were excluded if they met criteria for any current or lifetime axis I psychotic disorder, prior history of treatment with an antipsychotic, IQ <70 or past or current history of a clinically significant central nervous system disorder. In addition, control participants were also excluded if they had a first degree relative with a current or past psychotic disorder. Further details on ascertainment, inclusion and exclusion criteria have been described in detail elsewhere. Transition to psychosis was determined by meeting the presence of psychotic symptoms criteria.
Transition criteria is that at least one of the five SOPS positive symptoms reached a psychotic level of intensity for a frequency of ≥1 h per day for 4 days per week during the past month or that symptoms seriously impacted functioning .Vignettes were developed for each participant in order to obtain a consensus diagnosis both for study entry and for conversion. Raters from all sites reviewed the information on a weekly conference call, and consensus diagnosis decisions were made. Further information has been provided elsewhere. The structured interview for psychosis-risk syndromes and the scale of psychosis-risk symptoms were used to determine criteria for a prodromal syndrome and to determine severity of attenuated positive symptoms. Experience of trauma and abuse was assessed using a Childhood Trauma and Abuse scale, a semi-structured interview in which the interviewer enquires about trauma and abuse before the age of 16. The participant is asked about any emotional, physical, psychological or sexual abuse they may have experienced. In addition participants were asked if they had experienced either psychological bullying or physical bullying. A total trauma score was created to include the sum of emotional, physical, psychological and sexual abuse, and a total bullying score was created to include both psychological and physical bullying. Perceived discrimination was assessed using an adapted self-report measure. Participants answered ‘yes’ or ‘no’ to whether or not they had experienced discrimination in their lifetime because of their skin colour; ethnicity; gender; age; appearance; disability; sexual orientation; religion; or other reason. Total perceived discrimination was calculated as the total number of ‘types of discrimination’ that were endorsed.Chi square tests were used to compare categorical variables, and independent sample t tests were used to compare continuous variables.
Mann–Whitney U tests were used for comparison of total traumas and total perceived discrimination. Associations between type of trauma, total trauma, and total perceived discrimination to symptoms and ethnicity were examined using Spearman correlations. As per our previous analysis, ethnicity was divided into two sub-categories . Each of the individual predictors was then examined via a Cox proportional hazard regression model. The Assumption of proportionality of the hazard function over time was checked and the model satisfied the assumption. We first considered a model which included all the predictors that had a p value <0.25 in the univariate analyses, with an aim to drop the least significant variable, then continue by successively refitting the model and applying the same backward elimination rule until all remaining variables were statistically significant. Statistical analyses were conducted using SAS 9.4. This paper examined the impact that trauma and perceived discrimination have on the transition to psychosis among a large sample of individuals at risk for developing psychosis. Relative to controls the CHR group reported having experienced significantly more trauma, bullying, and endorsed more items on perceived discrimination. However, although trauma and bullying were not found to contribute to the prediction of psychosis, those who endorsed more items on the perceived discrimination scale had a greater chance of conversion to psychosis. Our results are somewhat in contrast to the results of previous studies reporting sexual abuse as a predictor of conversion to psychosis. This may be due to our lower rates of sexual abuse or differences in trauma measures in that the other studies used the General Trauma Questionnaire, or the Childhood Trauma Questionnaire. Regardless of this, consistent with other studies, we still found that CHR participants report significantly more levels of overall trauma compared to healthy controls. It is possible however,rolling 2×4 grow table that a past history of a trauma is a vulnerability factor for being at risk for psychosis and not a vulnerability factor for making the transition to psychosis once part of a high risk group. Additionally, similar to past reports, we found that with increased levels of reported trauma there were higher ratings on suspiciousness. However, it has to be noted that none of the correlations exceeded 0.22, which suggests that the relationship was relatively weak. In our sample perceived discrimination was a significant predictor of later conversion to psychosis. It is well established that the incidence of schizophrenia and other psychotic disorders are higher in ethnic minority groups, and it has been shown that perceived discrimination by ethnic minority groups, at least in studies conducted in Western Europe, may be contributing to this phenomenon. In addition, a study conducted in the USA demonstrating a twofold increase in schizophrenia in African–Americans suggests that being African–American is possibly an exposure to status discrimination such as neighborhood segregations, poorer education and fewer opportunities. The authors suggest that a “downstream effect of social racism, and a potential mediator of discrimination, is perceived discrimination”, . Furthermore, a recent paper demonstrates that in addition to ethnic minority position being associated with increased risk for psychosis, sexual minorities are also at risk for psychosis suggesting that exposure to minority stress in general may represent an important mechanism for the later development of psychosis. This fits with the “social defeat” theory offered by Selten and Cantor-Graae which provides some insight.
Social defeat is used to describe the chronic feeling of having an outsider status, or being in a subordinate position. Therefore, it may be that a chronic experience of perceived discrimination is contributing to a feeling of social adversity and outsider status, which is possibly driving this relationship. Furthermore, a separate study [30] has demonstrated that young adults with severe hearing impairments not only experience more feelings of social defeat but also demonstrate greater dopamine release in response to dexamphetamine. This supports the second part of the social defeat theory, which proposes that the chronic experience of social exclusion leads to a sensitization of the dopamine system. Interestingly, we observed that suspiciousness and disorganized communication were positively correlated with total perceived discrimination. These findings may help clarify the direction of this relationship in that perceived discrimination may have preceded the attenuated psychotic symptoms for some individuals but certainly did precede psychosis in our sample . Finally, as per our first paper, perceived discrimination was related to ethnicity, and in all participants, perceived discrimination was significantly associated with being from an ethnic minority. There are limitations to this study. Our measures of trauma and PD are brief. We do not have data on how often the trauma occurred, the age of the participant at the time of the trauma or the severity of the trauma. There is also the possibility of recall bias. Similarly, we do not have details on when the perceived discrimination first began. Lastly, given that those with a minority racial status were more likely than those with a Caucasian racial status to have missing perceived discrimination data, it is likely that this could have led to possible bias in the results. However, it should be noted that this observed difference was found among the control group only, and therefore would not have impacted any of the conversion to psychosis results. The strengths are that this is a large well-defined sample with longitudinal data. The consistently reported high rates of trauma in this population obviously warrant further attention, and may be an important area of intervention. A recent general population study [31] found that cessation of physical abuse and bullying predicted a cessation of psychotic like experiences. It should however be noted that this study was conducted in the general population and trauma was related to increased “psychotic like experiences”, so it is difficult to know if this would also apply to individuals who are meeting established CHR criteria. Sahin et al. suggest that clinicians be aware of these elevated rates among those at risk and make routine assessment of trauma history in clinical care. Lastly, given our previous findings that perceived discrimination was related to negative schemas, it may be that a pervasive negative sense of the self and others is contributing to an increase in perceptions of discrimination. It may therefore be relevant to address these concepts from a cognitive behavioral approach, in hopes to reduce or eliminate these maladaptive beliefs. It is also possible that the reverse is true, that the actual experience of discrimination leads to a pervasive negative sense of self and others. Determining the direction of this association may be important for future research. Finally, it may be that some of these young people are indeed outsiders and a treatment that focuses on skill and relationship development may be more useful than addressing beliefs. Lifetime risks for alcohol-related blackouts in many surveys is >50% among drinkers . The high blood alcohol concentrations involved and the compromised cognitive processes inherent in ARBs increase risks for additional serious consequences, including accidents, unwanted sex, and exposure to other forms of violence . In addition to BACs>.20g/dl needed for most blackouts, ARBs are also associated with European American [EA] ancestry, female sex, and several genetically-influenced phenotypes related to heavier drinking, including a low level of response to alcohol, as described further below . However, the relationships among these characteristics and ARBs are complex and their potential interactions have not been adequately evaluated .