We found that participants who tested positive for cocaine, particularly individuals with levels indicative of moderate to heavy use, had higher rates of disengagement from PrEP care. Marcus and colleagues found a similar pattern in their study of PrEP patients in an integrated healthcare system.In that study, patients with a documented history of drug use…
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It is possible that individuals may have experienced other traumatic events that we did not measure
Appointment adherence is the percentage of scheduled clinical appointments that were actually attended in the six months prior to the study visit. First, we generated descriptive statistics to summarize the baseline data. Second, we used bivariate linear and logistic regression analysis to examine relationships between trauma and various indicators of health. Third, we used bivariate linear…
They urge to creation of a universally unique and anonymous identifier to allow such linkages
A larger sample size can help clarify the results. Third, because the sample was naturalistic and included veterans with other comorbid non-PTSD and non-alcohol use disorders and concurrent medication use , such broad inclusion/exclusion criteria may have contributed to some of the non-significant findings given in Tables III and IV. A future study with more…
Various pandemic-related situational factors may differentially affect substance use problems
Participants also reported substantial amounts of substance use. On the NIDA Quick Screen, 69% of participants reported binge drinking, 78% tobacco use, 29% prescription drugs for non-medical reasons, and 51% illegal drugs in the past year. Of the 55 participants who reported use of illegal drugs or of prescription drugs for nonmedical reasons on the…
Its manualized treatment protocol ensures fidelity when the model is implemented in different settings
Genes that are differentially methylated from fetal to neonatal life stage include DRD2, NOS1, SOX10 and DNMT1, all of which have been previously found to be associated with schizophrenia. We also found DNMT1, NOS1 and SOX10 to be differentially methylated in brain tissue from patients with schizophrenia. However, after adjusting for age and autolysis, DRD2…
Physical activity decreases emotional stress and improves physical and psychological health
In the narrative excerpt above, her motivation was explicit and her logic clear when her father proved unresponsive to her telephone call. In semiotic terms, cutting was a concrete bodily hurt that stood as a sign, the object of which was her emotional hurt, and the interpretant of which was her need for emotional connection.…
Quikaine targets the neural system by increasing the speed of ion transfer between synaptic gaps
American providers – steeped in the Twelve Step tradition – recoil at the phrase “harm reduction” – but it is a service that they can and often do perform quite well. Perhaps the most socially beneficial treatment modality is one that some are reluctant to view as treatment at all – methadone maintenance for heroin…
Meconium was collected in the nursery on all infants of consented mothers
Infant neurobehavior was assessed with the NICU Network Neurobehavioral Scale , a measures that strongly correlates with scores on the 12 and 24 month Bayley exam in neonates born <37 weeks’ gestation. We previously reported preliminary data from the IDEAL study demonstrating that exposed neonates have decreased arousal, increased stress, and poor quality of movement…
This treatment attenuated the hyperactivity of both DAT KD mice and mice administered GBR12909
Infrared beams attached along all four walls and in each hole detect and record holepokes, rearing, and the location of the animal. Using these data, the BPM is able to quantify activity, exploration, and the structural patterns of motor activity of rodents . Previously, the rat and mouse BPM systems have proven useful to differentiate…
The prefrontal cortex is one of the last brain regions to complete its maturation
The suppression of gaping by URB was reversed by pre-treatment with the CB1 antagonist/inverse agonist, SR141716A, suggesting a CB1 mechanism of action. URB also interfered with the establishment of conditioned gaping when administrated before each pairing of the contextual stimuli with LiCl. This finding was consistent with that recently reported by Cross-Mellor et al. demonstrating that…